Why Pyloric Stenosis of Infancy Occurs--Simple Echos from the Past
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چکیده
Fasting gastrin levels rise steeply to levels exceeding adult fasting values after birth and do not fall despite the rising gastric acidity in the first few weeks of life. When both gastrin and acid secretion rise together (such as in the Zollinger-Ellison syndrome) the negative feedback between gastrin and antral acidity is not working [2,13,14]. During this time there is no post-prandial gastrin response since gastrin is maximally secreted without the constraint of an acid negative feed-back. In normal babies this early peak acidity does not trigger PS. It will simply confer a survival advantage by an increased resistance to enteric infections at that time [14]. In babies with an increased acid secreting ability, pyloric stenosis due to critical hyperacidity will be the natural result -and will present 2-3 weeks after birth.
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